ORGNTuesday, April 8, 2008

1:00 PM-4:40 PM Morial Convention Center -- Rm. R05, Oral
Biologically Active Molecules
Structure, Mechanism and Biological Activities
Presiding:Robert Aslanian
1:00 PMA reevaluation of the mechanism of cis-trans diastereomerization of GFP model chromophores
Laren M. Tolbert, Jian Dong, Fardokht Abulwerdi, Kyril M Solntsev
1:20 PMEffect of para-substitutions on cis-trans diastereomerization of GFP model chromophores
Fardokht Abulwerdi, Jian Dong, Laren M. Tolbert
1:40 PMAnnonaceous acetogenins: Targeting mitochondria for cancer therapy
Subhash C. Sinha, Zhiyong Chen, Fred Valeriote
2:00 PMDevelopment of conveniently functionalizable lipid analogs for investigating protein-lipid binding events
Michael Best, Matthew Smith, Denghuang Gong
2:20 PMExploring pH-sensitive NEBI linkers for cancer drug delivery applications
Alice Luong, Seong Deok Kong, Rina Fong, Lynnie Lin, Tawny Issarapanichkit, Jerry Yang
2:40 PMImproved pharmacokinetic properties of a polyethylene glycol-modified prostate-specific membrane antigen small molecules with preserved in vitro bioactivity
Preeti Misra, Kumar R. Bhushan, Fangbing Liu, John Frangioni
3:00 PMIncreased activity of dimeric 2-aminoimidazoles against Pseudomonas aeruginosa biofilms
T. Eric Ballard, Christian Melander
3:20 PMNoninvasive imaging of alphaVbeta6 integrin in fibrosis by multimerization of a nanomolar affinity 99m technetium-labeled small molecule
Preeti Misra, Kumar R. Bhushan, Popov Yuri, Nadine Pannier, Wolfgang Maison, Detlef Schuppan, John Frangioni
3:40 PMNovel bicyclic amidines as transition state analogs for glycosidases
Fedra M. Leonik, Nicole A. Horenstein
4:00 PMPhosphatidyl dihydroceramides, periodontitis and multiple sclerosis
Michael B. Smith, Amber Onorato, Frank Nichols, Shelli Boucher, Jennifer Pawlow
4:20 PMRegio-controlled nitration of Manzamine A as intermediates for producing Manzamine analogs with better docking scores with GSK-3b
Amir E. Wahba, Jiangnan Peng, Prasanna Sivaprakasam, Srinivas Odde, Robert J. Doerksen, Mark T. Hamann

Previous Session -- Biologically Active Molecules

Symposium Grid -- Division of Organic Chemistry -- Session Listing

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008