| MEDI | Sunday, April 6, 2008 | ||
7:00 PM-9:00 PM Morial Convention Center -- Hall A, Poster | |||
General Poster Session | |||
| Sponsored by: | MEDI | ||
| Financially supported by: | Eli Lilly and Company | ||
| Organizer: | James R. McCarthy | ||
| 23 | Design and synthesis of quinazoline derivatives as novel, potent multiacting HDAC and receptor tyrosine kinase inhibitors for the treatment of cancer Xiong Cai, Hai-Xiao Zhai, Cheng-June Lai, Rudi Bao, Changgeng Qian | ||
| 24 | Macrocyclic peptidyl biaryl-ether inhibitors provide evidence for the catalytic versatility of the 20S proteasome Marion G. Götz, Michael Groll, Markus Kaiser, Elisabeth Weyher, Luis Moroder | ||
| 25 | Design and synthesis of polyketide-based affinity labels for acyl carrier protein domains Erick K. Leggans, Robert A. Fecik | ||
| 26 | 2-Phenoxypyrimidine-5-carboxamide derivatives as a novel Prostaglandin D synthase inhibitor Keiko Yamane, Yoshiki Tanaka, Kazuhiko Shigeno, Toshiyuki Hosoya, Shin-ichi Inoue, Makoto Kitade, Takafumi Harada, Hiroki Aoyagi, Nao Miyoshi, Toshiharu Mutoh, Michinori Togawa, Mamoru Kiniwa, Yasundo Yamasaki | ||
| 27 | Cobalt(III) amine complexes as a potential antibacterial drugs Christa Simmers, Eddie L. Chang, D. Andrew Knight | ||
| 28 | Acute osteomyelitis (OM): Nanometer-sized calcium phosphate (CP) particles as a carrier for bisphosphonate-ciprofloxacin (E41) antibiotic James C McPherson III, Royce Runner, Pal Herczegh, Thomas B Buxton | ||
| 29 | First small molecule inhibitors of RecA in living bacteria Anna V. Gromova, Tim J. Wigle, Scott F. Singleton | ||
| 30 | Methods for purifying and detoxifying sodium dodecyl sulfate-stabilized polyacrylate nanoparticles Julio Cesar Garay, Danielle Gergeres, Ashley Young, Edward Turos | ||
| 31 | New classes of Gram-positive antibacterials: Inhibitors of MRSA and surrogates of the causative agents of anthrax and tuberculosis M. Shahjahan Kabir, Rebecca L. Polanowski, Aaron P. Monte, Marc A Rott, William R Schwan, James M. Cook | ||
| 32 | Synthesis of novel triazole-bearing nitroimidazoles with improved antimicrobial activity against the protozoan pathogen Giardia Carlos A. Valdez, Jaroslaw Kalisiak, Jonathan C. Tripp, Barbara Davids, Frances Gillin, Valery V. Fokin, K. Barry Sharpless, Lars Eckmann | ||
| 33 | Synthesis and biological activity of antagonists of AI-2-mediated bacterial quorum sensing in Vibrio harveyi Yunfeng Cheng, Nanting Ni, Minyong Li, Han-Ting Chou, Chung-dar Lu, Phang C Tai, Binghe Wang | ||
| 34 | Pyrogallol and its analogs can antagonize bacterial quorum sensing in Vibrio harveyi Nanting Ni, Gaurav Choudhary, Minyong Li, Binghe Wang | ||
| 35 | Synthesis of selectively functionalized steroid-2á, 3â-diol stereoisomer Sunil K Upadhyay, Branco S. Jursic | ||
| 36 | 2-Alkenyl thieno[2,3-b]pyridine-5-carbonitriles: Potent and selective inhibitors of PKCθ L. Nathan Tumey, Diane H. Boschelli, Divya Chaudhary, Julie Lee | ||
| 37 | Synthesis and study of anti-inflammatory resolvins derived from docosahexaenoic acid Nicos A. Petasis, Jasim Uddin, Jeremy Winkler, Rong Yang, Charles N. Serhan | ||
| 38 | Synthesis and study of neuroprotectin D1, a potent antii-nflammatory lipid mediator Nicos A. Petasis, Jasim Uddin, Jeremy Winkler, Rong Yang, Nicolas G. Bazan, Charles N. Serhan | ||
| 39 | Synthesis and study of polyisoprenyl phosphate analogs as regulators of acute inflammation Nicos A. Petasis, Kalyan C. Nagulapalli, Raquel Keledjian, Bruce D. Levy, Charles N. Serhan | ||
| 40 | Preparation and lead optimization of potent neurokinin-2 receptor antagonists Michael F. Parker, Robert Bertekap, Joanne J. Bronson, Neil Burford, Angela Cacace, John E. Macor, Kimberly Marmora, Ryan Westphal | ||
| 41 | Novel 5-HT2A/D2/Sigma receptor ligands: Psychiatric disorder treatment agents Yong-Gil Kim, Joon Heo, Seon-Min Dong, Yun-Hee Kim, Byong-Sung Kwak | ||
| 42 | Synthesis and structure-activity relationship of a series of alpha-azole substituted phenyl alkyl amines as 5-HT2A/D2 receptor ligands: Potential psychosis treatment agents Yong-Gil Kim, Joon Heo, Mi-Kyung Ji, Nahm-Ryune Cho, Man-Young Cha, Byong-Sung Kwak | ||
| 43 | Structure activity relationship and pharmacological evaluation of carbamic acid benzoyl piperidine analog: YKP1358, novel atypical antipsychotics Yong-Gil Kim, Joon Heo, Seon-Min Dong, Mi-Kyung Ji, Byong-Sung Kwak | ||
| 44 | Synthesis and SAR of pyridinyl-pyrazole derivatives as selective 5HT2A inverse-agonists for platelet aggregation Peter I. Dosa, Bradley R. Teegarden, Jarrod Davidson, Martin Casper, John Adams, Juan Ramirez, William Thomsen, Diane Yuskin | ||
| 45 | Discovery and SAR of highly selective 5-HT2A receptor subtype inverse-agonists for inhibition of platelet aggregation Yifeng Xiong, Bradley R. Teegarden, Jin Sun Choi, Sonja Strah-Pleynet, Marc Decaire, Honnappa Jayakumar, Peter I. Dosa, Martin Casper, Lan Pham, Konrad Feichtinger, Brett Ullman, John Adams, Juan Ramirez, William Thomsen, Diane Yuskin, Michael Morgan, Abu Sadeque, Weichao Chen, Hussien Al-Shamma, Graeme Semple, Robert R. Webb, Daniel Connolly | ||
| 46 | Targeting serotonin transporter channel activity aids in the development of therapeutic drugs for clinical depression Uyen M. Le, Hideki Iwamoto, Hongping Yuan, Lou DeFelice, Craig W Lindsley | ||
| 47 | Tetrahydroindolizinone NK1 antagonists: SAR at 7-position Jianming Bao, Huagang Lu, Gregori J. Morriello, Emma Carlson, Richard Tschirret-Guth, Gary G. Chicchi, Marc Kurtz, Kwei-lan Tsao, Song Zheng, Xinchun Tong, Sander Mills, Robert DeVita | ||
| 48 | Tuning affinity on a tropane framework for dopamine D2/D3 receptor subtype ligands Noel M. Paul, Christina Z. Floresca, Michelle Taylor, Robert R. Luedtke, Jeffrey R. Deschamps, Amy H. Newman | ||
| 49 | Design, synthesis and evaluation of novel azole nucleoside analogs for their activity against hantaviruses Sidath C. Kumarapperuma, Marjan Jeselnik, Dong-Hoon Chung, Yanjie Sun, Qianjun Li, Yong-Kyu Chu, William B. Parker, Colleen B. Jonsson, Jeffrey B. Arterburn | ||
| 50 | Homology modeling and molecular dynamics simulation of Hepatitis B virus DNA polymerase: Validation using molecular docking Pankaj R. Daga, Robert J. Doerksen | ||
| 51 | Design and synthesis of 3-deazaneplanocin A derivatives Chong Liu, Stewart W. Schneller | ||
| 52 | Discovery of novel oxadiazolyl phenyl derivatives as herpes helicase-primase inhibitors with potent activity against HSV and VZV Toru Kontani, Junji Miyata-Sato, Wataru Hamaguchi, Akio Kamikawa, Tomoaki Kawano, Hiroshi Suzuki, Kenji Sudo, Makoto Takeuchi, Mitsuaki Ohta | ||
| 53 | Design and synthesis of a series of 7-substituted 2-(4-fluorobenzyl)-9-hydroxy-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,6,8(7H)-trione inhibitors of HIV-1 Integrase and viral replication in cells Mark W. Embrey, H. Marie Langford, Theresa Booth, Peter Williams, John Wai, Joseph Vacca, Daria J. Hazuda, Michael D. Miller, Peter J. Felock, Kara A. Stillmock, William A. Schleif, Lori J. Gabryelski, Lixia Jin, Joan D. Ellis, Terry A. Lyle | ||
| 54 | Tricyclic 10-hydroxy-7, 8-dihydropyrazinopyrrolopyrazine-1, 9-diones as potent, orally bioavailable HIV-1 integrase strand transfer inhibitors Catherine M. Wiscount, Lekhanh O. Tran, Mark W. Embrey, Thorsten E. Fisher, Vanessa Sherman, Donnette D. Staas, Peter Williams, John Wai, Terry A. Lyle, Joseph Vacca, Peter J. Felock, Marc V. Witmer, Lori Gabryelski, Michael D. Miller, Daria J. Hazuda, Linda Ecto, WA. Schleif, Christopher J. Kochansky, M. Reza Anari | ||
| 55 | Discovery and synthesis of a potent long-acting inhibitor of HIV integrase Debra S. Perlow, Melissa Egbertson, John Wai, Linda S. Payne, Wei Han, Cuthbert D. Martyr, Vanessa E. Obligado, Kristi L. Hoffman, Joseph Vacca, Daria J. Hazuda, Peter J. Felock, Kara A. Stillmock, William A. Schleif, Lori Gabryelski, M. Reza Anari, Joan Ellis, Marc V. Witmer, Michael Miller, Nancy N. Tsou, Mirlinda Biba, Christopher J. Welch, Terry A. Lyle | ||
| 56 | Synthesis of 5,6-dihydropyran-2-ones as potential inhibitors of HIV-1 protease Jesse L. Nye, Levente Fabry-Asztalos | ||
| 57 | Synthesis and antiviral properties of 8-aza-7-deaza-Aristeromycin and Neplanocin Haisheng Wang, Yan Zhang, Stewart W. Schneller | ||
| 58 | Preparation and antiviral activity of N-1 / N-2 methyl-4-deazacarbaformycin Yan Zhang, Haisheng Wang, Stewart W. Schneller | ||
| 59 | Early screening for PXR- and CAR-mediated ADME-Tox liabilities: New fluorescence-based ligand binding and coregulator recruitment assays William J. Frazee, Upinder Singh, Bryan D. Marks, Hildegard C. Eliason, Deborah K. Stafslien, Jill K. Wolken, Kurt W. Vogel | ||
| 60 | Fluorescence detection of nucleic acids triggered by DNA-templated chemical reaction Kazuhiro Furukawa, Hiroshi Abe, Wang Jin, Kazuma Oki, Miwako Uda, Satoshi Tsuneda, Yoshihiro Ito | ||
| 61 | New fluorescence-based assays for identification and characterization of selective PPARa, d(b), and g ligands Upinder Singh, Bryan D. Marks, Hildegard C. Eliason, Deborah K. Stafslien, Jennifer M. Wilkinson, Therese De Rosier, Tina M. Hallis, Kurt W. Vogel, Guobin Miao, William J. Frazee | ||
| 62 | Caco-2 cell based assay development for tight junction modulating peptides Kelly M. Kitchens, Shobha Gopalakrishnan, John Vere, Rosa Carrasco, Min Li, Ed Oliver, Mark Ginski, Niranjan Pandey, Blake Paterson, Sefik S. Alkan, Amir P. Tamiz | ||
| 63 | Identification and hit to head optimization of a series of pkc theta inhibitors for t cell mediated diseases Magda Asselin | ||
| 64 | Indole-phenylacetic acid inhibitors of CRTH2 Michael G. Johnson, Jiwen Liu, An-Rong Li, Yingcai Wang, Wang Shen, Sarah Lively, Yongli Su, Bettina van Lengerich, Xuemei Wang, Sujen Lai, Matt Brown, Shauna Lawliss, Ying Sun, Qingge Xu, Tassie Collins, Jay Danao, Lisa Seitz, Mark Grillo, Jill Wait, Julio Medina | ||
| 65 | Synthesis and evaluation of a series of 7-substituted-8-azaquinazolinone CXCR3 antagonists Darin J. Gustin, Phillipe Bergeron, Johann Chan, Xiaoqi Chen, Jeff Diegnan, Du Xiaohui, Jeff MIhalic, Theresa Carabeo, Collins Tassie, Lemon Brian, George Tonn, Julio C. Medina | ||
| 66 | Paper Withdrawn | ||
| 67 | Synthesis and evaluation of 2-aryl-thieno[2,3-b]pyridine-5-carbonitriles as PKCtheta inhibitors Biqi Wu, Diane H. Boschelli, Julie Lee, Xiaoke Yang, Divya Chaudhary | ||
| 68 | Synthesis and pharmacology of the novel HA-MTX conjugate (DK226) for osteoarthritis Haruhiko Sato, Akira Okamachi, Takashi Emura, Akie Honma, Takenori Ishizawa, Tatsuya Kato, Tetsu Matsuura, Shigeo Sato, Tatsuya Tamura, Yoshinobu Higuchi, Tomoyuki Watanabe, Hidetomo Kitamura, Kentaro Asanuma, Tadao Yamazaki, Masahisa Ikemi, Hironoshin Kitagawa, Tadashi Morikawa, Kazuaki Maeda, Koichi Takahashi, Kenji Nohmi, Noriyuki Izutani, Makoto Kanda, Ryochi Suzuki | ||
| 69 | Investigation of ketone warheads as alternatives to the nitrile for preparation of potent and selective cathepsin k inhibitors Michael J. Boyd, Sheldon N. Crane, Joel Robichaud, John Scheigetz, Cameron Black, Nathalie Chauret, Qingping Wang, Frédéric Massé, Renata Oballa | ||
| 70 | Synthesis of bisphosphonates designed for selective attachment to proteins Jivan Yewle, Yinan Wei, David Puleo, Leonidas Bachas | ||
| 71 | Discovery of potent T-type calcium channel blocker Han Na Seo, Ja Youn Choi, Yun Jeong Choe, Jungahn Kim, Dong Joon Choo, Jae Yeol Lee | ||
| 72 | Synthesis and SAR studies of a novel series of T-type calcium channel blockers Yun Jeong Choe, Han Na Seo, Ja Youn Choi, Jungahn Kim, Dong Joon Choo, Jae Yeol Lee | ||
| 73 | Thiols oxidation and covalent binding of BSA by cyclolignanic quinones are enhanced by the magnesium cation Ajay Kumar, Antonio E. Alegria, Pedro Sanchez-Cruz, Carmelo García, Fernando A. Gonzalez, Aimee Orellano, Beatriz Zayas, Marina Gordaliza | ||
| 74 | Synthesis of 7-substituted benzyl-5-[(3,4,5-trimethoxyphenyl)ethyl]-4-methyl- 7H-pyrrolo[2, 3-d]pyrimidin-2-amines as microtubule inhibitors Aleem Gangjee, Sonali Kurup, Charles D. Smith | ||
| 75 | Synthesis of analogs of trienomycin A, a potential inhibitor of Hsp90 Geraldine Calvet, Brian Blagg | ||
| 76 | Synthesis and biological activities of pyrrolo-pyridazine derivatives TANG Peng Cho, FENG Jun, ZHANG Lei, BIE Ping Yan | ||
| 77 | Probing the structure-activity relationships of tubulysins Ranganathan Balasubramanian, Bhooma Raghavan, Robert A. Fecik | ||
| 78 | P2 site SAR development toward ABT-263, an orally bioavailable inhibitor of Bcl-2 family proteins Xiaohong Song, Milan Bruncko, Hong Ding, Aaron R Kunzer, Christopher Lynch, Cheol-Min Park, Andrew M Petros, Xilu Wang, Michael D Wendt, Paul M Nimmer, Morey L. Smith, Stephen K Tahir, Haichao Zhang, Christin Tse, Andrew J. Souers, Saul Rosenberg, Steven W Elmore | ||
| 79 | Identification of pyrazolo[1,5-a]pyrimidine-3-carboxylates as B-Raf kinase inhibitors: Part 1 Ariamala Gopalsamy, Greg Ciszewski, Yongbo Hu, Frederick Lee, Larry Feldberg, Eileen Frommer, Steven Kim, Karen Collins, Donald Wojciechowicz, Robert Mallon | ||
| 80 | Phenylpyrazolo[1,5-a]pyrimidines as B-Raf Inhibitors: Optimization of phenyl group: Part 2 Greg Ciszewski, Ariamala Gopalsamy, Jeremy I. Levin, Kyung-Hee Kim, Yongbo Hu, Frederick Lee, Larry Feldberg, Eileen Frommer, Steven Kim, Karen Collins, Donald Wojciechowicz, Robert Mallon | ||
| 81 | Phenylpyrazolo[1,5-a]pyrimidines as B-Raf Inhibitors: Optimization of pyrazolopyrimidne ring substituents: Part 3 Mengxiao Shi, Ariamala Gopalsamy, Dan M. Berger, Minu Dutia, Yongbo Hu, Frederick Lee, Larry Feldberg, Eileen Frommer, Steven Kim, Karen Collins, Donald Wojciechowicz, Robert Mallon | ||
| 82 | Synthesis and SAR of 1,2,3,4-tetrahydro-pyrido[2,3-b]pyrazines as c-Met and ALK inhibitors Linda R. Weinberg, Mark S. Albom, Thelma S. Angeles, Bruce D. Dorsey, Jean Husten, Karen L. Milkiewicz, Seetha Murthy, Douglas A. Pippin, Renee Roemmele, Ted L. Underiner | ||
| 83 | Targeted binding of chitosan-based nanoparticles with galactose ligand to HepG2 cells Ting Wang, Zhangqi Feng, Wenjing Yang, Nongyue He | ||
| 84 | Antibody conjugates for cancer therapy Subhash C. Sinha, Zhengzheng Huang | ||
| 85 | Studies of plant virus capsids as promising protein carriers for carbohydrate based anticancer vaccine development Adeline Miermont, Xiaowei Lu, Katherine Wall, Qian Wang, Xuefei Huang | ||
| 86 | Targeting RING finger domain of HDM2 for cancer therapy Zengjian Hu, Lei Liu | ||
| 87 | Total synthesis of new cytotoxic diterpenes Daniel Rabouin, Lionel Dumas, Eric Beaulieu, Kenza Daïri, Samuel Fortin, Eric Fournier, Gerson G. Gonzalez, Sasmita Tripathy, Sylvie Bailly, Gaetan Gagnon, Sandra Naranjo, Brigitte St-Denis, Nancy Steenaart, Jean-François Lavallee, Giorgio Attardo, Pierre Beauparlant, Xavier Billot, Laurent Bélec | ||
| 88 | Trifluoromethyl substituted pyrrole 2-indolinone derivatives as tyrosine kinase inhibitors TANG Peng Cho, BIE Ping Yan, LIU Wei Li, YANG Shi Bo, ZHANG Lei, FENG Jun | ||
| 89 | Using novobiocin analogs to probe the C-terminus of Hsp90 Alison C. Donnelly, Brian S. J. Blagg | ||
| 90 | 3-D-QSAR studies on benzothiadizapine hydroxamates as tumor necrosis factor-alpha converting enzyme inhibitors Prashant R. Murumkar, Rajani Giridhar, Mange Ram Yadav | ||
| 91 | A nonclassical NF- κB pathway in HUVEC cells revealed by small molecule probes Yidong Liu, Gangli Gong, Yuli Xie, Alison Rinderspacher, Shi-Xian Deng, Donald W. Landry, Michael Wyler, Nathalie Aulner, Udo Toebben, Deborah H. Smith, Lars Branden, Caty Chung, Stephan Schürer, Dušica Vidović | ||
| 92 | Discovery of novel small molecule activators of NFkB pathway Gangli Gong, Yuli Xie, Yidong Liu, Alison Rinderspacher, Shi-Xian Deng, Donald W. Landry, Michael Wyler, Nathalie Aulner, Udo Toebben, Deborah H. Smith, Lars Branden, Caty Chung, Stephan Schürer, Dušica Vidović | ||
| 93 | GGTase I as an anticancer drug target: Development of GGPP analog SAR Michelle Maynor, Richard F. Borch, Richard A. Gibbs | ||
| 94 | Identification and optimization of N3, N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors Xiaolin Hao, David Kopecky, XianYun Jiao, Yi Chen, Jiasheng Fu, Juan Jaen, Holger Wesche, Josh Xiao, Edward van der Horst, Jinsong Liu, Zhulun Wang, Mario Cardozo, Ji Ma, Shichang Miao, Liang Tang, Frank Kayser | ||
| 95 | Signaling protein modulators as therapeutic agents based on tyrphostin dimer like structure Zhenghong Peng, Ashutosh Pal, David S Maxwell, William Bornmann, Shimei Wang, Nicholas Donato, Moshe Talpaz | ||
| 96 | Paper Withdrawn | ||
| 97 | Bispurine polyamine analogs of spermine: Synthesis and growth inhibitory effects on human prostate cancer cells Shashikant Phadtare, Tien Banh, Tien Chung, Nageswara Kode | ||
| 98 | Design and synthesis of pyrazolone-based anaplastic lymphoma kinase (ALK) inhibitors Robert J. McHugh, Rabindranath Tripathy, Thelma Angeles, Mark Albom, Mangeng Cheng, Bruce Dorsey | ||
| 99 | Development of novel anticancer agent via cell-cycle arrest Sung Hoon Ha, Han Na Seo, Yun Jeong Choe, Ja Youn Choi, Jungahn Kim, Dong Joon Choo, Jae Yeol Lee | ||
| 100 | Discovery of 2-(3-pyridyl)-4-arylaminopyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay Nilantha Sirisoma, Azra Pervin, Bao Nguyen, Candace Crogan-Grundy, John Drewe, Ben Tseng, Shailaja Kasibhatla, Sui Xiong Cai | ||
| 101 | Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a potent apoptosis inducer using anticancer screening apoptosis program (ASAP), a cell- and caspase-based platform Sui Xiong Cai, Nilantha Sirisoma, Azra Pervin, Hong Zhang, Songchun Jiang, Vijay Baichwal, J. Adam Willardsen, Mark Anderson, Christopher M. Pleiman, Ben Tseng, Shailaja Kasibhatla, John Drewe | ||
| 102 | Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based HTS assay: Modifications of the 2- and 3-positions William Kemnitzer, Songchun Jiang, Yan Wang, Shailaja Kasibhatla, Candace Crogan-Grundy, Monica Bubenik, Denis Labrecque, Real Denis, Serge Lamothe, Giorgio Attardo, Henriette Gourdeau, Ben Tseng, John Drewe, Sui Xiong Cai | ||
| 103 | Discovery of N-aryl-9-oxo-9H-fluorene-1-carboxamides as a new series of apoptosis inducers using a cell- and caspase-based HTS assay: SAR of the N-aryl group Nilantha Sirisoma, William Kemnitzer, Bao Nguyen, Shailaja Kasibhatla, Candace Crogan-Grundy, Ben Tseng, John Drewe, Sui Xiong Cai | ||
| 104 | Virtual screening of natural compound library against N-Cadhein protein to identify new anticancer agents Li Bai, Zengjian Hu | ||
| 105 | Lead optimization of 2-amino-3-benzyloxy-5-pyrazol-4-yl-pyridine for the discovery of clinical candidate PF-2341066 as potent and highly selective c-Met inhibitor Michelle Tran-Dube, Hong Shen, Shinji Yamazaki, Helen Zou, James Christensen, Barbara Mroczkowski, J. Jean Cui | ||
| 106 | 1,2-Dialkynylimidazoles: Anticancer aza-enediynes Christophe Laroche, Mireya L. McKee, Sean M. Kerwin | ||
| 107 | Synthesis and evaluation of potential antitumor antimitotics that also reverse tumor resistance Aleem Gangjee, Charles D. Smith, Nilesh Zaware | ||
| 108 | Synthesis of substituted pyrrolo [2, 3-d] pyrimidines with N7 chain length difference as novel antitumor antimitotic agents that also reverse tumor resistance Aleem Gangjee, Xin Zhang, Charles D. Smith | ||
| 109 | Synthesis of benzo[4,5]thieno[2,3-d]pyrimidine as potential dual TS and DHFR inhibitor Aleem Gangjee, Xilin Zhou, Xin Zhang, Roy L. Kisliuk | ||
| 110 | ABT-263, an orally bioavailable inhibitor of Bcl-2 family proteins Hong Ding, Cheol-Min Park, Milan Bruncko, Christopher Lynch, Aaron R Kunzer, Andrew M Petros, Xiaohong Song, Xilu Wang, Michael D Wendt, Paul M Nimmer, Morey L. Smith, Stephen K Tahir, Haichao Zhang, Christin Tse, Andrew J. Souers, Saul Rosenberg, Steven W Elmore | ||
| 111 | Carbonyl reductase inhibition as a means to increase anthracycline efficacy Christopher K. Ewing, Henry A. Charlier Jr. | ||
| 112 | Comparisons between parthenolide and a new agent against acute myelogenous leukemia Ekkawit Chanchorn, Y. N. Vashisht Gopal, T. Randall Lee, Michael W. Van Dyke | ||
| 113 | Design and synthesis of small-molecule inhibitors of the HIF-1 pathway Suazette Reid, Vladimir Belozerov, Erwin G Van Meir, Binghe Wang | ||
| 114 | Discovery of a novel indenoheterocycle with potent apoptosis inducing properties through a systematic study of a multicomponent reaction involving indane-1,3- dione, adehydes and various amine-containing heterocyclic compounds Alexander Kornienko, Yin Shan C. Wong, Lisa A. Anderson, Amber Ortega, Madhuri Manpadi, Karen M. Cotter, Severine Van Slambrouck, Wim Steelant, Snezna Rogelj, Scott T Shors, Igor V. Magedov | ||
| 115 | Effect of o-phenoxy caspase inhibitors on apoptosis Benjamin K Southerland, William Grunwald Jr., Kashmira Kulkarni-Datar, Chanel Hagler, Daniel M. Ketcha, Thomas L. Brown, David R. Cool | ||
| 116 | Paper Withdrawn | ||
| 117 | Multicomponent synthesis and anticancer evaluation of a library of novel indenopyridopyrimidines Alexander Kornienko, Lisa A. Anderson, Yin Shan C. Wong, Amber Ortega, Madhuri Manpadi, Steven Brock, Severine Van Slambrouck, Wim Steelant, Snezna Rogelj, Scott T Shors, Igor V. Magedov | ||
| 118 | New cathepsin D inhibitors: Synthesis and evaluation Rose M. McConnell, Priya Velusamy, Darryl Driver, Kelley L. Sayyar, Carol J. Trana, Walter E. Godwin | ||
| 119 | Novel cannabinoids for the treatment of neuropathic pain obtained by Pd nanoparticle–catalyzed cyclization/cross-coupling tandem reaction Philippe Diaz, Jijun Xu, Fanny Astruc Diaz, Hao-Min Pan, Mohamed Naguib | ||
| 120 | Novel purine based "atypical retinoids" as antitumor agents Shashikant Phadtare, Tien Chung, Tien Banh, Devangachinta Murthy | ||
| 121 | Synthesis and structure-activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked cap group Po C Chen, Vishal Patil, William R Guerrant, Patience Green, Adegboyega K Oyelere | ||
| 122 | Cancer: Using tumor growth simulations to design treatment protocols Nemoy Rau, Ileana Carpen | ||
| 123 | Inhibition of platelet aggregation via P2Y12 receptor antagonists: Synthesis, SAR, chemical stability data, and biological results Paul S. Watson, Stephanie A. Anderson, James G. Douglass, José L. Boyer, Christopher S. Crean, Sanjoy Mahanty, Anna K. Morgan, Rozemarijn S. Verhoeven, Carl A. Samuelson | ||
| 124 | Efficient removal of ruthenium-based catalysts using SiliaBond® metal scavengers Geneviève Gingras, Annie Michaud, Lynda Tremblay, Steeves Potvin, François Béland | ||
| 125 | 3,3-Diarylacrylonitriles as tubulin polymerization inhibitors for cancer chemotherapy Zhenglai Fang, Mark Cushman, Ernest Hamel, Gregory E. Agoston | ||
| 126 | Molecular basis of the selectivity of fluorinated neurotransmitters for adrenergic receptors Chaya Pooput, Erica Rosemond, Stefano Costanzi, Francesca Deflorian, Kenneth L. Kirk, Jürgen Wess | ||
| 127 | Synthesis and SAR of a partial mGluR5 antagonist lead: Unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold Sameer Sharma, Richard Williams, Alice L Rodriguez, Colleen M Niswender, Charles D. Weaver, P. Jeffrey Conn, Craig W Lindsley | ||
| 128 | Practical application of quantum mechanics to drug design: A tour of hydrogen bond donors and acceptors of perennial interest to the medicinal chemist Daniel L. Cheney, Dale Braden | ||
| 129 | Raising HDL levels by a small molecule LCAT activator Frank Kayser, Jian Zhang, Marc Labelle, Preston Ford, Sindhu Padmanabhan, Mingyue Zhou | ||
| 130 | Synthesis and biological evaluation of analogs of Altohyrtin C (Spongistatin 2) Carl Edward Wagner, Qiang Wang, Clayton H. Heathcock | ||
| 131 | Synthesis and biological evaluation of c-12' substituted vinflunine derivatives LEI Xin Sheng, TANG Peng Cho, YU Xiang Da, LIU Zhen Hong, LV He Jun, YIN Long, YANG Fang Long | ||
| 132 | Investigation of glyburide and its metabolites in urine and plasma of pregnant patients under treatment for gestational diabetes Selvan Ravindran, Olga Zharikova, Tatiana Nanovskaya, Ronald Hill, Donald Mattison, Gary Hankins, Mahmoud Ahmed | ||
| 133 | Synthesis and structure-activity relationship of pyridyl sulfonamide 11-β-HSD1 inhibitors David S. Yoon, Shung C. Wu, James Li, Haixia Wang, Ligaya M. Simpkins, Zheming Ruan, Christopher B. Cooper, Katy Van Kirk, Zhengping Ma, Ramakrishna Seethala, Rajasree Golla, Akbar Nayeem, Stanley R. Krystek Jr., David A. Gordon, Jeffrey A. Robl, Lawrence G. Hamann | ||
| 134 | Multiple chemical ligation under thermal cycle Yuko Kondo, Hiroshi Abe, Hiroshi Jinmei, Naoko Abe, Kyoko Aikawa, Isamu Matsumoto, Yoshihiro Ito | ||
| 135 | Identification of AT-1002 as a mucosal permeability modulator Min Li, Ed Oliver, John Vere, Kelly M. Kitchens, Mark Ginski, Shobha Gopalakrishnan, Niranjan Pandey, Sefik S. Alkan, Blake Paterson, Amir P. Tamiz | ||
| 136 | Semi-automatic permeability vs. pH profile assay for pharmaceutical drugs using a diffusion cell and a PC-controlled UV spectrophotometer Arno Kraft, Nicola M. Howarth, Joanne C. Morris, Claire Knox | ||
| 137 | Spectroscopic study of cyclodextrin inclusion complexes with A-007 prodrugs Sarada Sagiraju, Branko S. Jursic | ||
| 138 | Synthesis and biological evaluation of isophosphoramide mustard(IPM)prodrugs Sukhen Ghosh, David Farquhar, Yunming Ying | ||
| 139 | Preparation of polymeric spheres encapsulating photosensitizers for the treatment of leishmaniasis Swathi Gannavaram, David L. Cedeño, Marjorie A. Jones | ||
| 140 | Preparation and evaluation of novel porphyrins incorporated in liposomes to treat leishmaniasis Shruti Padhee, David L. Cedeño, Marjorie A. Jones | ||
Symposium Grid -- Division of Medicinal Chemistry -- Session Listing
The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008