| MEDI | Tuesday, April 8, 2008 | ||
2:15 PM-5:30 PM Morial Convention Center -- Rm. 244/245, Oral | |||
General Oral Session | |||
| Sponsored by: | MEDI | ||
| Financially supported by: | Advanced Chemistry Development, Inc., (ACD/Labs) | ||
| Organizer: | James R. McCarthy | ||
| 2:15 PM | 174 | Discovery of MK-4965: A potent, orally bioavailable HIV-1 nonnucleoside reverse transcriptase inhibitor (NNRTI) with improved potency against key mutant viruses I Thomas J Tucker, Sandeep Saggar, John T Sisko, Robert M Tynebor, Peter J. Felock, Jessica A Flynn, Ming-Tain Lai, Yuexia Liang, Meiquing Liu, Georgia McGaughey, Michael D. Miller, Gregory Moyer, Vandna Munshi, Rebecca A. Poehnelt, Sridhar Prasad, Rosa I. Sanchez, Maricel Torrent, Joseph P Vacca, Theresa M. Williams, Bang-Lin Wan, Youwei Yan | |
| 2:35 PM | 175 | Discovery of MK-4965: A potent, orally bioavailable HIV-1 nonnucleoside reverse transcriptase inhibitor (NNRTI) with improved potency against key mutant viruses II Thomas J Tucker, Sandeep Saggar, John T Sisko, Robert M Tynebor, Peter J. Felock, Jessica A Flynn, Ming-Tain Lai, Yuexia Liang, Meiquing Liu, Georgia McGaughey, Michael D. Miller, Gregory Moyer, Vandna Munshi, Rebecca A. Poehnelt, Sridhar Prasad, Rosa Sanchez, Maricel Torrent, Joseph P Vacca, Theresa M. Williams, Bang-LIn Wan, Youwei Yan | |
| 2:50 PM | 176 | Design, synthesis, and biological evaluation of potent c-met inhibitors Noel D. D'Angelo, Steve Bellon, Shon K. Booker, Teresa L. Burgess, Celia Dominguez, Isabelle Dussault, Ingrid Fellows, Randall W. Hungate, Matthew Lee, Longbin Liu, Elizabeth Rainbeau, Paul J. Reider, Aaron Siegmund, Andrew Tasker, Ning Xi, Shimin Xu, Tae-Seong Kim | |
| 3:10 PM | 177 | Structure based drug design for the discovery of clinical candidate PF-2341066 as potent and highly selective c-Met inhibitor J. Jean Cui, Iriny Botrous, Hong Shen, Michelle Tran-Dube, Mitchell Nambu, Pei Pei Kung, Lee Funk, Lei Jia, Jerry Meng, Mason Pairish, Michele McTigue, Neil Grodsky, Kevin Ryan, Gordon Alton, Shinji Yamazaki, Helen Zou, James Christensen, Barbara Mroczkowski | |
| 3:30 PM | 178 | Design, synthesis and optimization of several novel NNRTI series Lyn H. Jones | |
| 3:50 PM | 179 | Design, synthesis, and evaluation of fused heterocyclic analogs as adenosine A2A receptor antagonists Unmesh Shah, Craig D. Boyle, Samuel Chackalamannil, William J. Greenlee, Claire Lankin, Bernard Neustadt, Mary Cohen-Williams, Ahmad Fawzi, Guy Higgins, Jean Lachowicz, Kwokei Ng, Geoffrey Varty, Hongtao Zhang | |
| 4:10 PM | 180 | Small molecule antagonists of the Histamine receptor type3 (H3) as a novel treatment for cognitive dysfunction Ji-In Kim, Magid Abou-Gharbia, Suzan Aschmies, Nicholas Brandon, Thomas Comery, Mark Day, Jonathan Gross, Warren D. Hirst, Cody Kelley, Katie Kubek, Ronald L. Magolda, Menelas Pangalos, William R. Solvibile, Gregory J. Tawa, Albert J Robichaud | |
| 4:30 PM | 181 | Indoleazepines as a new class of nonsteroidal agonists of the farnesoid X receptor: Identification of WAY-362450 (FXR-450) as a clinical candidate for the treatment of dyslipidemia Paige E. Mahaney, Douglas C. Harnish, Magid A. Abou-Gharbia, Eric Bischoff, Lisa Borges-Marcucci, Mark J. Evans, Brenton T. Flatt, Elizabeth Gantan, Stephen J. Gardell, Xiao-Hui Gu, KehDeh Lai, Ronald L. Magolda, Richard Martin, Raju Mohan, Peter Ordentlich, Ira Schulman, Rayomand J. Unwalla, George P. Vlasuk, Shuguang Wang, Tie-Lin Wang, Stefan Westin, Jay E. Wrobel, Weixin Xu, Grace Yan, Songwen Zhang | |
| 4:50 PM | 182 | Substituted-pyrrole 2-amino-3,5-dihydro-4H-imidazol-4-ones as highly potent and selective BACE1 inhibitors William F. Fobare, Michael S. Malamas, Albert J Robichaud, William R. Solvibile, Ping Zhou, Dominick A. Quagliato, Jim Erdei, Iwan Gunawan, Yinfa Yan, Patrick M. Andrae, Jim Turner, Erik Wagner, Yun Hu, Kristi Yi Fan, Suzan Aschmies, R. Chopra, Jonanthan Bard | |
| 5:10 PM | 183 | Synthesis and transport studies on serine side-chain-linked peptidomimetic prodrugs of cyclic cidofovir Larryn W Peterson, Boris A. Kashemirov, Monica Sala-Rabanal, Jae-Seung Kim, Stefanie Mitchell, Paul Kijek, John Hilfinger, Charles E. McKenna | |
Symposium Grid -- Division of Medicinal Chemistry -- Session Listing
The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008