ORGN 542 |
| Methyl-branched fatty acids are commonly found in bacteria.(1) Several of these branched short-chain fatty acids have been reported to have antitumor or antimicrobial activity.(2) The 4,9-dimethyldecanoic acid was isolated for the first time in nature from the halophilic bacterium Bacillus sp. from the salt pans of Burgas in Bulgaria.(3) A synthetic scheme to obtain 4,9-dimethyldecanoic acid was developed to provide enough material to perform bioassays in order to assess possible biological activities. The 4,9-dimethyldecanoic acid will be obtain as a single enantiomer, since the synthesis starts with a chiral starting material. The advances in this synthesis will be presented. (1) Chou, S.; Chedore, P.; Haddad, A.; Paul, N. R.; Kasatiya, S. J. Clin. Microbiol. 1996, 34, 1317-1320. (2) Adamczeski, M.; Reed, A. R.; Crews, P. J. Nat. Prod. 1995, 58, 201-208. (3) Carballeira, N. M.; Miranda, C.; Lozano, C. M.; Nechev, J. T.; Ivanova, A.; Stefanov, K.; Ilieva, M.; Tzvetkova, I. J. Nat. Prod. 2001; 64, 256. |
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Materials, Devices and Switches, Metal-Mediated Reactions, Asymmetric Reactions, Total Synthesis, Biologically-Related Molecules and Processes
7:00 PM-9:00 PM, Wednesday, April 9, 2008 Morial Convention Center -- La Louisiane, Blrm. C, Poster
Division of Organic Chemistry |