ORGN 69 |
| Efficient synthetic methods required to assemble complex molecular arrays include reactions that are both selective (chemo-, region- and stereo-) and economical in atom count. Development of chemoselective methodology at low cost and avoiding potential hazards is a step towards green chemistry. Reduction is one of the most fundamental and useful reactions in organic chemistry. NaBH4 is a mild and versatile reagent used for chemoselective reduction of carbonyl compounds. Various methods for enhancement of reactivity and selectivity of NaBH4 such as NaBH4-ZrCl4, NaBH4-SnCl2, NaBH4-MnCl2, and NaBH4-Al2O3 in aprotic and protic have been reported in the literature for the reduction of aldehydes and ketones. In depth studies of NaBH4 promote us to investigate the selective reduction of carbonyls in phase transfer catalyst. This presentation will focus on the chemoselective reduction of carbonyls to corresponding alcohols with NaBH4 in polyethylene glycol as phase transfer catalyst. The new synthetic methodology is efficient and eco-friendly. |
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Physical Organic Chemistry, Combinatorial and Process Chemistry, New Reactions and Methodology, Peptides, Proteins and Amino Acids
8:00 PM-10:00 PM, Sunday, April 6, 2008 Morial Convention Center -- Hall A, Poster
Division of Organic Chemistry |