CARB 5 |
| A new class of functionalized polyamines with RNA-binding properties has been developed. These molecules are derived from amino acids, and the synthesis proceeds by reductive amination between alpha-amino aldehydes. The resulting oligomers have been tested for binding to TAR RNA, an RNA fragment with a stem-loop structure that is important for replication of HIV. The results of binding studies will be presented, along with recent results from cell-based assays. Finally, the extension of this chemistry to the synthesis of combinatorial libraries along with high throughput screens for RNA binding will be described. |
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RNA as a Drug Target
8:20 AM-1:20 PM, Sunday, April 6, 2008 Morial Convention Center -- Rm. 214, Oral
Division of Carbohydrate Chemistry |