Application of the hetero-Pauson-Khand reaction to complex molecule synthesis

ORGN 215

William E. Crowe, wcrowe1@lsu.edu, Jongtae Yang, Maria A. Appeaning, mariaapp@hotmail.com, Anne M. Sauer, and Steve Lawrence, slawre4@lsu.edu. Department of Chemistry, Louisiana State University, 710 Choppin Hall, Baton Rouge, LA 70803-1804

Application of the hetero-Pauson-Khand (HPK) reaction to the synthesis of several classes of complex molecules will be described with emphasis on novel, versatile routes to HPK substrates and stereoselectivity issues encountered in HPK bicyclization reactions.  Efficient routes to HPK substrates such as 2 and 3 will be discussed as well as conversion of the substrates to complex polycyclic targets (such as 1).

 

Metal-Mediated Reactions and Synthesis
8:00 AM-12:00 PM, Monday, April 7, 2008 Morial Convention Center -- Rm. R06, Oral

Division of Organic Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008