ORGN 148 |
| Synthesis of α-aminonitriles by direct three component Strecker reaction has been achieved using environmentally friendly solid acid catalysts Nafion-H® (a perfluoroalkanesulfonic acid polymer) and Nafion®SAC-13 (Nafion-H® polymer on amorphous silica, 10-20%). Silica gel and fumed silica are also shown to have significant catalytic activity towards the Strecker reaction. These catalysts are more convenient and safer in comparison with many conventional acid catalysts. The Strecker reaction is the most popular approach towards the synthesis of biologically important α-amino acids through the formation of α-aminonitriles. Simple and clean reactions with relatively easy product separation, high yield and purity of the products, easy catalyst recovery and recycling are the salient features of the current methodology. Due to these advantages these solid catalysts can be considered as effective “green” catalysts for one-pot Strecker reaction. Studies with fluoroacetone show that fluorinated α-aminonitriles (precursors of biologically active fluorinated α-amino acids) can also be prepared by Strecker reaction using these catalysts. Environmentally friendly (green) catalysts are making great contributions towards sustainable development. |
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Physical Organic Chemistry, Combinatorial and Process Chemistry, New Reactions and Methodology, Peptides, Proteins and Amino Acids
8:00 PM-10:00 PM, Sunday, April 6, 2008 Morial Convention Center -- Hall A, Poster
Division of Organic Chemistry |