Direct intramolecular arylation of aryl halides

ORGN 588

Olafs Daugulis, olafs@uh.edu and Gan B. Bajracharya, ganbajracharya@yahoo.com. Department of Chemistry, University of Houston, 4800 Calhoun Rd., 136 Fleming Bldg, Houston, TX 77204
In continuation of our ongoing projects on copper-catalyzed direct arylations through C–H activation, we found an efficient direct intramolecular arylation reaction of aryl halides under basic conditions for the coupling of aryl moieties via aryne intermediate. The coupling reaction proceeds efficiently under moderate to high temperatures in a variety of solvents.