ORGN 559 |
| Progress towards the “thread and cut” synthesis of a trefoil knot containing only 72 atoms in its backbone will be presented. The eight-step synthetic route involves Etherifications and an azide-alkyne Click-cycloaddition step for the knot precursor (Figure). A Ring-closing metathesis reaction is used for tying the knot followed by ester hydrolysis (the "cut" step), leading to what we term ECR knots. Use of NMR chiral shift reagents for characterization will also be discussed.
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Materials, Devices and Switches, Metal-Mediated Reactions, Asymmetric Reactions, Total Synthesis, Biologically-Related Molecules and Processes
7:00 PM-9:00 PM, Wednesday, April 9, 2008 Morial Convention Center -- La Louisiane, Blrm. C, Poster
Division of Organic Chemistry |
