ORGN 415 |
| Indoles and pyridines have been overrepresented in drug molecules due to their ease of synthesis and abundance of commercial derivatives. While these compounds add potentially useful properties, space within these molecules is used inefficiently limiting their continued utility. We have been pursuing the synthesis of related, historically underrepresented classes of compounds with additional heteroatoms and saturation patterns – tetrahydro-naphthiridines, thienopyridines, dihydro-azaindoles. These molecules have physiochemical advantages over pyridines and indoles, and also provide more varied electronic properties, potential binding sites, and binding modes. Through the course of these studies, we have built in the possibility of multiple substitution patterns to allow optimization during the drug discovery process. This has resulted in the generation of new families of previously unavailable compounds and the discovery of novel chemistry related to these compounds.
|
|
Heterocycles and Aromatics, Molecular Recognition and Self Assembly
8:00 PM-10:00 PM, Tuesday, April 8, 2008 Morial Convention Center -- Hall A, Poster
Division of Organic Chemistry |
