ORGN 116 |
| Substituted morpholine derivatives are found in many compounds of pharmacological value. The efficient synthesis of novel substituted morpholine derivatives can open the door to explore new drugs. We recently reported the atom transfer cyclization catalyzed by In(III) and, importantly, we found that the reaction was driven by catalytic halide activation by under mild conditions. We have also discovered other C-C bonds formations via catalytic halide activation including ring-closing Friedel-Crafts reactions and 5-exo-trig cyclizations. We have extended this halide activation to the cynthesis of 2,6-disubstituted morpholine derivatives. Details of the diastereoselective formation of 2,6-disubstituted morpholines via In(III)-catalyzed O-allylation will be presented.
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Physical Organic Chemistry, Combinatorial and Process Chemistry, New Reactions and Methodology, Peptides, Proteins and Amino Acids
8:00 PM-10:00 PM, Sunday, April 6, 2008 Morial Convention Center -- Hall A, Poster
Sci-Mix
Division of Organic Chemistry |
