Chiral lactones are important architectures found in a variety of macrolide antibiotic structures.  Traditional strategies for generating lactones rely on the coupling of alcohols and carboxylic acids using stoichiometric coupling reagents such as 2,4,6-trichlorobenzoyl chloride/DMAP, ethyl azodicarboxylate/PPh₃, DCC and 2-halopyridinium salt.  This poster describes a catalytic and atom economical synthesis of lactones directly from aldehydes and ketones.  Our approach involves an unpredecedented reduction of ketones to generate chiral lactones in up to 99% ee.  The mechanism, scope, and limitations of this process will be discussed.