ORGN 576 |
| N-substituted glycine oligomers, or “peptoids,” are a class of biomimetic molecules which can be efficiently synthesized to incorporate a diverse range of side-chains in a sequence-specific manner. The versatility and synthetic ease of these molecules make them suitable candidates for a wide range of materials applications. Here, we demonstrate the use of peptoids in conjunction with the copper-catalyzed [3+2] cycloaddition of azides and alkynes to generate branched polymer networks. It is shown that by incorporating both azides and alkynes onto the molecular scaffold, peptoids can form cross-linked macromolecules in the presence of copper. Furthermore, by attaching a thiourea group onto the oligomer, these molecules can be localized onto a copper metal surface, allowing for increased network proliferation which in turn generates macroscopic films. This novel procedure provides a direct method for the chemical modification of metal surfaces.
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Materials, Devices and Switches, Metal-Mediated Reactions, Asymmetric Reactions, Total Synthesis, Biologically-Related Molecules and Processes
7:00 PM-9:00 PM, Wednesday, April 9, 2008 Morial Convention Center -- La Louisiane, Blrm. C, Poster
Division of Organic Chemistry |
