New twist on an old technique: 1H acquired PP spectroscopy (HAPPY)

ORGN 626

Meha H. Shah, meha@jhu.edu1, Ananya Majumdar, ananya@jhu.edu2, and Caren L. Freel Meyers1. (1) Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N. Wolfe St., Wood Basic Sciences Bldg, Baltimore, MD 21205, (2) Biomolecular NMR Facility, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218
A suite of proton detected 2-dimensional H,P-NMR techniques have been developed. These techniques allow for the highly sensitive and detailed characterization of small molecules through proton-phosphorus connectivity. This technique is especially useful for identifying H-P-P-H networks, allowing for differentiation between ring-open and ring-closed structures. We have applied this technique to the characterization of structurally diverse phosphorylated and polyphosphorylated species. Further potential as a method for kinetic analysis of phosphorus containing metabolites can also be envisioned.

 

Materials, Devices and Switches, Metal-Mediated Reactions, Asymmetric Reactions, Total Synthesis, Biologically-Related Molecules and Processes
7:00 PM-9:00 PM, Wednesday, April 9, 2008 Morial Convention Center -- La Louisiane, Blrm. C, Poster

Division of Organic Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008