Asymmetric transfer hydrogenation of ketones: Development of amino acid derived transition metal catalysts

ORGN 565

Jenny Wettergren, jennyw@organ.su.se, Alexey B. Zaitsev, and Hans Adolfsson. Department of Organic Chemistry, Stockholm University, Arrhenius Laboratory, SE-106 91 Stockholm, Sweden
Asymmetric transfer hydrogenation (ATH) of ketones is an efficient, safe and operationally simple method for the production of enantiomerically enriched alcohols.

We have developed a number of highly selective catalysts for the ATH based on simple α-amino acid ligands.

Herein we present our latest findings on the use of naturally occurring amino acids as chiral ligand building blocks for the in situ formation of efficient ATH catalysts.

 

Materials, Devices and Switches, Metal-Mediated Reactions, Asymmetric Reactions, Total Synthesis, Biologically-Related Molecules and Processes
7:00 PM-9:00 PM, Wednesday, April 9, 2008 Morial Convention Center -- La Louisiane, Blrm. C, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Sci-Mix

Division of Organic Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008