Copper-catalyzed synthesis of high enantiopurity peptidic ketone by peptidic thiol ester and boronic acid cross coupling

ORGN 132

Hao Yang, hyang5@emory.edu, Hao Li, hli23@emory.edu, and Lanny S. Liebeskind. Department of Chemistry, Emory University, 1515 Dickey DR NE, Atlanta, GA 30322
A general and efficient peptidic ketone synthesis was developed from peptidic thiol ester and boronic acid cross coupling using only catalytic Copper(I) 3-methylsalicylate under the air. This reaction is realized from the introduction of a specific template group on the thiolester (thiosalicylamides).
 

Physical Organic Chemistry, Combinatorial and Process Chemistry, New Reactions and Methodology, Peptides, Proteins and Amino Acids
8:00 PM-10:00 PM, Sunday, April 6, 2008 Morial Convention Center -- Hall A, Poster

Division of Organic Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008