Poly(styrene) resin supported dendronized Co(Salen) catalysts as novel catalytic systems

ORGN 220

Poorva Goyal, pg51@nyu.edu1, Xiaolai Zheng, xiaolai.zheng@chemistry.gatech.edu1, and Marcus Weck, marcus.weck@nyu.edu2. (1) School of Chemistry and Biochemistry, Georgia Institute of Technology, 770 State Street, Atlanta, GA 30332-0400, (2) Molecular Design Institute and Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003-6688
Catalysis plays a key role in the efficient and facile synthesis of organic compounds and biomolecules in the pharmaceutical and fine chemical industry. Among the most versatile catalysts for the enantioselective synthesis of organic compounds are the metallosalens developed by Jacobsen and Katsuki. Resin supported catalysis provides an attractive means of recycling catalysts and improving catalytic activities. We will present a (R,R)-(salen)CoCl that was immobilized on poly(styrene) resin through a generation 1 dendron. The design rational is that due to the bimetallic nature of the transition state involved in the cobalt salen catalysis, the placement of catalytic sites near another along the immobilized dendron should allow increase catalytic activity along with recyclability.
 

Metal-Mediated Reactions and Synthesis
8:00 AM-12:00 PM, Monday, April 7, 2008 Morial Convention Center -- Rm. R06, Oral

Division of Organic Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008