ORGN 460 |
| The polypropionate framework constitutes a very common structural motif in a number of biologically active natural products, a classic example of which is the macrolide antibiotic Erythronolide B. Progress made towards the total synthesis of Erythronolide B will be presented. Our group has previously developed the direct enantioselective synthesis of β-lactones via asymmetric acyl halide aldehyde cyclocondensation (AAC).The β-lactones derived from the AAC reactions can act as direct surrogates for propionate-aldol products. The synthesis will involve the iterative use of the AAC methodology to construct adjacent propionate units in the molecule.
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Total Synthesis of Complex Molecules
8:00 AM-12:00 PM, Wednesday, April 9, 2008 Morial Convention Center -- Rm. R05, Oral
Division of Organic Chemistry |
