Development of new synthetic methodologies and strategies toward the total synthesis of daphnicyclidin alkaloids

ORGN 583

David R Williams, williamd@indiana.edu and Partha P Nag, pnag@indiana.edu. Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, IN 47405
A tandem carbolithiation/electrocyclization/alkylation methodology has been developed in the context of the total synthesis of Daphnicyclidins, which are a family of alkaloids isolated be Kobayashi from the stems of Daphniphyllum humile and D. Teijsmanni. A mechanistic investigation and application of this unique cascade reaction will be documented. A progress report of the studies towards the total synthesis of daphnicyclidin F will be presented.
 

Materials, Devices and Switches, Metal-Mediated Reactions, Asymmetric Reactions, Total Synthesis, Biologically-Related Molecules and Processes
7:00 PM-9:00 PM, Wednesday, April 9, 2008 Morial Convention Center -- La Louisiane, Blrm. C, Poster

Division of Organic Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008