ORGN 614 |
| We report Pd-catalyzed conditions for converting diverse aryl bromides to the corresponding primary anilines using benzophenone imine or tert-butyl carbamate as ammonia equivalents. The reaction conditions are mild (RT to 30 °C) and have general substrate scope. In some cases, the methods are complementary with respect to functional group compatibility. In addition, tert-butyl carbamate has emerged as a convenient ammonia equivalent, providing a robust handle (as the Boc-protected aniline) to conduct further reactions prior to deprotection of the aniline.
|
|
Materials, Devices and Switches, Metal-Mediated Reactions, Asymmetric Reactions, Total Synthesis, Biologically-Related Molecules and Processes
7:00 PM-9:00 PM, Wednesday, April 9, 2008 Morial Convention Center -- La Louisiane, Blrm. C, Poster
Division of Organic Chemistry |
