One-Pot enyne metathesis Brønsted acid-promoted heterocycle formation

ORGN 219

Kyle P Kalbarczyk, kk66@buffalo.edu and Steven T. Diver, diver@buffalo.edu. Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260
Enyne metathesis has become a synthetically powerful method for the catalytic synthesis of conjugated dienes. The enyne metathesis furnishes dienes which can be functionalized by cycloadditions. However, the availability of additional, distinct functionalization reactions will increase the versatility of the diene synthesis. In this presentation, the development of a new acid promoted diene functionalization reaction is described. Our findings demonstrate that this is an effective synthesis for a variety of heterocycles and can be conducted in an efficient, one-pot transformation.