Synthesis of benzothiazoles

ORGN 378

Afsha A. Rais, Arais@mail.smu.edu, Department of Chemistry, Southern Methodist University, Southern Methodist University, Dallas, TX 75275 and Edward R. Biehl, ebiehl@mail.smu.edu, Department of Chemistry, SMU, Dallas, TX 75275.
In our continuing studies on the use of microwave heating for preparing heterocyclic compounds, we report the preparation of a series of 1, 2- Benzothiazoles. Benzothiazole derivatives have pharmacological activities such as anti-tumor drugs, anti-inflammatory and antibacterial. The benzothiazoles were synthesized by the reaction of 2-chloroacetophenone derivates with ammonium iodide, sodium acetate, and sulfur. The reaction conditions were in DMF at 90 oC for 10 minutes. All the products were characterized by 1HNMR, 13CNMR and GC/MS.
 

Heterocycles and Aromatics, Molecular Recognition and Self Assembly
8:00 PM-10:00 PM, Tuesday, April 8, 2008 Morial Convention Center -- Hall A, Poster

Division of Organic Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008