ORGN 165 |
| A convenient approach has been developed for iodolactonisation using iodobenzene as catalyst. The active reagent was identified as diacetyloxyiodate(I) and was generated in situ with tetra-n-butylammonium iodide (TBAI) and hypervalent iodine reagent, diacetoxyiodobenzene (PIDA). PIDA, in turn, was generated in situ using a catalytic amount of iodobenzene with sodium perborate monohydrate as the stoichiometric oxidant. A variety of olefinic acids including ä-pentenoic acids, ä-pentynoic acids and ä-hexynoic acid gave high yields of lactones using this methodology. |
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Physical Organic Chemistry, Combinatorial and Process Chemistry, New Reactions and Methodology, Peptides, Proteins and Amino Acids
8:00 PM-10:00 PM, Sunday, April 6, 2008 Morial Convention Center -- Hall A, Poster
Sci-Mix
Division of Organic Chemistry |