Bicyclic guanidine-catalyzed enantioselective phospha-Michael reactions

ORGN 166

Xiao Fu, g0403051@nus.edu.sg and Choon-Hong Tan, chmtanch@nus.edu.sg. Department of Chemistry, National University of Singapore, 3 Science Drive 3, S8-03-01, 117543, Singapore, NA, Singapore
Chiral bicyclic guanidine (2,6-di-tert-butyl-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazole) has been found catalyzed the Phospha-Michael reaction of diaryl phosphine oxide to nitrostyrenes with high enantioselectivities. This is a direct and atom economical methodology for the preparation of chiral á-substituted â-aminophosphines oxides and â-aminophosphines with high enantioselectivities. These novel aminophosphines are potentially usefeuu as catalyst and ligands in metal catalyzed reactions.
 

Physical Organic Chemistry, Combinatorial and Process Chemistry, New Reactions and Methodology, Peptides, Proteins and Amino Acids
8:00 PM-10:00 PM, Sunday, April 6, 2008 Morial Convention Center -- Hall A, Poster

Division of Organic Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008