ORGN 428 |
| Recently, trioxanes 1 (R = various) have attracted considerable attention as a new class of synthetic anti-malarials. Unfortunately, the range of drug candidates is limited by the need to minimize inactivation of the pharmacophoric trioxane moiety and surround it with bulky substituents, and the need to incorporate water-solubilizing groups to compensate for the bulky substituents. “Transferring” the protection and solubilization of the trioxane moiety to a supramolecular nano-capsule is one way to expand the list of potential drug candidates. Towards this, we will report on how complexation within capsular dimers of 2 influences the stabilization of these molecules.
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Heterocycles and Aromatics, Molecular Recognition and Self Assembly
8:00 PM-10:00 PM, Tuesday, April 8, 2008 Morial Convention Center -- Hall A, Poster
Division of Organic Chemistry |
