ORGN 457 |
| The epothilones are a novel class of microtubule stabilizing anti-cancer natural products which have gained much interest by the synthetic community. Also, rationally designed analogues have met with success in clinical trials, therefore further prompting us to explore the correlation between conformational analysis and biological activity. We have recently shown that C-14 substitution can have a significant effect on conformation and biological activity. The synthesis and biological activity of 14-methoxy epothilone D will be presented.
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Total Synthesis of Complex Molecules
8:00 AM-12:00 PM, Wednesday, April 9, 2008 Morial Convention Center -- Rm. R05, Oral
Division of Organic Chemistry |
