ORGN 172 |
| Polycyclic indole alkaloids represent a diverse range of biologically important natural products. Herein we present the development of simple synthons that facilitate rapid entry into the Aspidosperma alkaloid framework. Our studies have focused on Lewis acid activation of N,O-trimethylsilyl acetals derived from tryptamine and simple carboxylic acids. The scope and limitations of the resulting cascade reactions will be discussed.
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Physical Organic Chemistry, Combinatorial and Process Chemistry, New Reactions and Methodology, Peptides, Proteins and Amino Acids
8:00 PM-10:00 PM, Sunday, April 6, 2008 Morial Convention Center -- Hall A, Poster
Sci-Mix
Division of Organic Chemistry |
