ORGN 31 |
| Despite recent advances in the field of C-H functionalization, methods transforming sp3 C-H bonds into new C-C bonds remain rare. We have recently developed a general hydroalkylation methodology for a variety of sp3 C-H bonds via a [1,5] hydride transfer/cyclization cascade. This intramolecular-redox strategy requires no stoichiometric oxidants or reagents and is catalyzed by simple Lewis acids. We have also observed significant rate enhancements through the use simple organic molecules as co-catalysts. These strategies will be discussed along with reaction scope and applications in complex organic synthesis.
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New Reactions and Methodology
8:00 AM-12:00 PM, Sunday, April 6, 2008 Morial Convention Center -- Rm. R04, Oral
Division of Organic Chemistry |
