ORGN 41 |
| Metal-responsive fluorescent probes are powerful tools for exploring the biological chemistry of trace elements in living cells. To develop fluorescent probes for the selective detection of zinc and monovalent copper in a cellular environment, several different fluorescence switching mechanisms were explored, including cation-induced excited state intramolecular proton transfer, photoinduced electron transfer, as well as modulation of intramolecular charge transfer states through cation coordination and conformational switching. Detailed analysis of the underlying photophysical mechanisms allowed for precise tuning of the fluorescence properties and switching responses. |
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Novel Fluorophores
1:00 PM-5:30 PM, Sunday, April 6, 2008 Morial Convention Center -- Rm. R05, Oral
Division of Organic Chemistry |