Three component, highly diastereoselective metal free synthesis of 2,3,4,5 tetrasubstituted pyrrolidines

ORGN 120

Luis Crovetto, Luiscrovetto@ugr.es and Ramon Rios, riosramon@yahoo.com. Department of Physical Chemistry, University of Granada, Cartuja Campus, Granada 18071, Spain, 18071 Granada, Spain
An extremely efficient, highly diastereselective, metal-free synthesis of 2,3,4,5 tetrasubstituted pyrrolidines is described. The three component reaction between aldehyde, aminomalonate and nitroalkenes proceeds with high diastereoselectivities and high yields
 

Physical Organic Chemistry, Combinatorial and Process Chemistry, New Reactions and Methodology, Peptides, Proteins and Amino Acids
8:00 PM-10:00 PM, Sunday, April 6, 2008 Morial Convention Center -- Hall A, Poster

Division of Organic Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008