ORGN 427 |
| Hydrogen bonding is seen extensively in nature through the motifs of DNA/RNA nucleobase pairing and as secondary structures in protein folding. New hydrogen-bonded polymeric assemblies have been designed and synthesized that make use of Watson-Crick hydrogen bonding of guanosine and cytidine. By synthesizing linear, metal-nucleobase, and carbene-nucleobase systems, a variety of new supramolecular polymeric systems, shown below, are being studied. While nucleobases are good candidates for supramolecular polymer formation, they can also be utilized, in combination with amino acids, to provide a nucleobase-protein tag, which could capture or bind to a nucleic acid sequence based on sequence complementarity. While complementarity would be provided through the nucleobases, they are directly attached to serine, which is used to embed the tag into the protein. By directing enzymatic function to a particular sequence, these new components can be used as agents in gene therapy.
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Heterocycles and Aromatics, Molecular Recognition and Self Assembly
8:00 PM-10:00 PM, Tuesday, April 8, 2008 Morial Convention Center -- Hall A, Poster
Division of Organic Chemistry |
