Microwave-assisted greener synthesis of pharmaceutically active heterocycles under benign conditions

ORGN 425

Vivek Polshettiwar, polshettiwar.vivek@epa.gov and Rajender S. Varma, Varma.Rajender@epa.gov. Sustainable Technology Division, National Risk Management Research Laboratory, U. S. Environmental Protection Agency, 26 W. Martin Luther King Dr., MS 443, Cincinnati, OH 45268
Green chemistry is a rapidly developing new field that provides us a proactive avenue for the sustainable development of future science and technologies. Environmentally benign protocols have been developed for the synthesis of various pharmaceutically active heterocycles namely 1,3,4-oxadiazoles, 1,3,4-thiadiazoles, 1,3-dioxanes, pyrazoles, hydrazones and 3,4-dihydropyrimidin-2(1H)-ones, which proceed under the influence of microwave irradiation and using eco-friendly conditions. These high-yielding greener protocols were catalyzed efficiently by solid supported NafionŽNR50, phosphorus pentasulfide on alumina (P4S10/Al2O3) under solvent-free conditions and polystyrene sulfonic acid (PSSA) in aqueous media.

 

Heterocycles and Aromatics, Molecular Recognition and Self Assembly
8:00 PM-10:00 PM, Tuesday, April 8, 2008 Morial Convention Center -- Hall A, Poster

Division of Organic Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008