ORGN 160 |
| Primary sulfonamides represent a useful structural motif in biologically active molecules. Their syntheses, though conceptually simple and straightforward, often suffer from low to moderate yields. In our search for a universal high yielding synthetic method amenable for parallel syntheses we found two major obstacles: 1/ formation of bis- sulfonylated materials and/or 2 / insufficient conversion. Herein we describe an efficient protocol for a one pot synthesis of primary sulfonamides featuring utilization of excess of sulfonylating agent followed by base mediated recovery of the primary sulfonamide. The scope of the process and its applicability will be discussed
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Physical Organic Chemistry, Combinatorial and Process Chemistry, New Reactions and Methodology, Peptides, Proteins and Amino Acids
8:00 PM-10:00 PM, Sunday, April 6, 2008 Morial Convention Center -- Hall A, Poster
Division of Organic Chemistry |
