ORGN 408 |
| Among the challenges for chemists include discovery and development of novel and simple environmentally safe chemical processes for selective synthesis by identifying alternative reaction conditions and solvents for much improved selectivity, energy conservation and less or no toxic waste generation and inherently safer chemical products. Therefore, to address depletion of natural resources and preservation of ecosystem it is just urgent to adopt so called “greener technologies” to make chemical agents for well being of human health. Schiff's bases are reported to show characteristic biological activities including antibacterial, antifungal, anticancer and herbicidal properties. Other application of Schiff's bases includes industrial synthesis of high value life saving beta lactam antibiotics from class of penicillins and cephalosporins. The number of useful properties prompted us to synthesize these Schiff bases and develop cleaner methods to scale up. We have synthesized Schiff's bases using classical organic chemistry methods as well as by heating key raw materials using microwave irradiations. In our experiments we have studied number of reaction parameters such as duration of reaction, isolation, purity, yield of products and ease of work up procedure. As expected we have observed significant advantages while using microwave radiations for heating the reactants. The structural determination and their confirmation using both technologies were done by elemental analysis, IR, 1H-NMR and Mass spectroscopy. Comparative study and advantages of microwave irradiation for Schiff's bases synthesis over conventional methods will be presented. |
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Heterocycles and Aromatics, Molecular Recognition and Self Assembly
8:00 PM-10:00 PM, Tuesday, April 8, 2008 Morial Convention Center -- Hall A, Poster
Division of Organic Chemistry |