Fluorescent nucleobase replacements: Building blocks for pi-stacked architectures and fluorophore libraries

ORGN 39

James N. Wilson, jnwilson@stanford.edu, Yin Nah Teo, yinnah@stanford.edu, Younjin Cho, younjin@stanford.edu, and Eric T. Kool, kool@stanford.edu. Department of Chemistry, Stanford University, Stanford, CA 94305-5080
Fluorescent nucleosides have proven useful as reporters or sensors in bioassays and detection schemes. We have developed a strategy to produce a wide variety of photophysical outcomes by assembling the fluorophores along the DNA backbone encouraging optical and electronic interactions between neighboring ‘bases'. Access to thousands of new polyfluorophores can be achieved through the synthesis of combinatorial libraries. The sequence dependent emission and an investigation of neighboring base effects in these pi-stacked architectures will be presented.
 

Novel Fluorophores
1:00 PM-5:30 PM, Sunday, April 6, 2008 Morial Convention Center -- Rm. R05, Oral

Division of Organic Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008