ORGN 462 |
| Littorachalcone, a biologically active polyphenol, was found to be useful in the treatment of various neurological disorders including Parkinson's and Alzheimer's disease. A direct and convergent synthesis of littorachalcone will be presented. A bis-aldol reaction was used as a key step involving 2,4-dimethoxyacetophenone and suitably functionalized 4,4'-oxybisbenzaldehyde. Reduction of resulting bis-enone by NiCl2-NaBH4 followed by removal of protecting groups furnished the target molecule in an efficient manner. Some analogues of Littorachalcone were also synthesized. Their biological activitiy was also tested. |
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Total Synthesis of Complex Molecules
8:00 AM-12:00 PM, Wednesday, April 9, 2008 Morial Convention Center -- Rm. R05, Oral
Division of Organic Chemistry |