ORGN 656 |
| Lipoarabinomannan (LAM), a glycolipid, is one of several organic structures that “protects” the cell surface of Mycobacterium tuberculosis. The proximate sub-unit is a phosphoinositol(di)mannoside (PIM) pseudotrisaccharide, which is anchored to the membrane by lipid residues, usually (shown as) two or three in number. However Puzo recognizes FOUR such lipids on PIM, which require different synthetic demands. A synthesis of bio-synthetically important PIM2Ac4, in which the four acyl groups are different, will be described.
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Materials, Devices and Switches, Metal-Mediated Reactions, Asymmetric Reactions, Total Synthesis, Biologically-Related Molecules and Processes
7:00 PM-9:00 PM, Wednesday, April 9, 2008 Morial Convention Center -- La Louisiane, Blrm. C, Poster
Sci-Mix
Division of Organic Chemistry |
