ORGN 243

High activity and uniform high levels of stereocontrol, not only in model reactions, and readily accessible chiral ligands are among the desirable features of an ideal catalyst for practical asymmetric synthesis. Furthermore a modular design of new chiral ligands will allow rapid fine tuning of asymmetric catalysis for a particular class of chiral substrates. Bidentate chiral ligands have been the ligands of choice to reach high levels of stereocontrol for several decades. In this lecture it is demonstrated that high activity and stereoselectivity is not a privilege of catalysts based on bidentate ligands. We introduced monodentate phosphoramidites as highly effective novel ligands for asymmetric catalysis.Progress in asymmetric hydrogenation and C-C bond formation will be discussed. New approaches in catalyst screening, exploiting chiral space based on combinatorial libraries of monodentate phosphorus ligands, will also be presented.