Cascade reactions in complex alkaloid synthesis

ORGN 305

Mohammad Movassaghi, movassag@mit.edu, Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 18-292, Cambridge, MA 02139
Several representative enantioselective alkaloid total syntheses will be discussed. Of particular interest to these programs is the development of unifying strategies for each alkaloid family of interest guided by biosynthetic hypotheses that enable maximum use of the inherent chemistry of intricate potentially biomimetic intermediates. These strategic considerations along with related mechanistic studies direct the development of concise total syntheses.
 

Herbert C. Brown Award for Creative Research in Synthetic Methods: Symposium in Honor of Eric N. Jacobsen
1:30 PM-5:10 PM, Tuesday, April 8, 2008 Morial Convention Center -- La Nouvelle, Blrm. C, Oral

Division of Organic Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008