Enantioselective organocatalytic tandem Michael-aldol reactions

ORGN 596

Hao Li, haoli@unm.edu, Jian Wang, Liansuo Zu, zls@unm.edu, Hexin Xie, xiehexin@unm.edu, Wei Jiang, and Wei Wang, wwang@unm.edu. Department of Chemistry and Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001
Tandem or cascade reactions are a powerful tool for rapid assembly of complex structures. Unlike stepwise bond formation toward a target molecule, such process has the advantages of greatly enhanced synthetic efficiency, while producing less waste and minimizing the excessive handling. Organocatalytic enantioselective tandem processes are even more appealing because of their operational simplicity and environmental friendliness. In this poster, we would like to present an organocatalyzed enantioselective one-pot Michael-aldol reactions that enable facile access to the useful “privileged” structures: thiobenzopyrans, benzopyrans and hydroquinolines from simple achiral molecules in high yields and high enantioselectivities.