ORGN 464 |
| Plants of the family Guttiferae produce polycyclic polyprenylated acylphloroglucinols (PPAPs), which have interesting biological including anticancer and antibacterial properties. The main structural features of PPAPs comprise of bicyclo[3.3.1]nonane-2,4,9-triketone with one acyl group together with prenyl, geranyl, or other C10H17 groups. Few research groups have published synthetic strategies for the PPAPs with the C-7 prenyl group in the endo orientation. The synthesis of type B PPAP natural products, including xanthochymol and 7-epi-clusianone, is being approached by syn reduction of an alkyne with Co2(CO)8 and Et3SiH and an intramolecular aldol reaction.
|
|
Total Synthesis of Complex Molecules
8:00 AM-12:00 PM, Wednesday, April 9, 2008 Morial Convention Center -- Rm. R05, Oral
Division of Organic Chemistry |
