ORGN 343 |
| 4-isopropylphenyl boronic acid was synthesized by Grignard reagent, and an optimized process was obtained by investigating the influence of the temperature and reactant proportion on the yield. First, Grignard reagent was prepared (yield is 98.2%), and then reacted with tributyl borate at 263 K, then hydrolyzed in a acid medium after the temperature was increased to room temperature in a short time. The isolated yield is 56.6%. The product was verified by 1H NMR and mass spectrum characterization. |
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Heterocycles and Aromatics, Molecular Recognition and Self Assembly
8:00 PM-10:00 PM, Tuesday, April 8, 2008 Morial Convention Center -- Hall A, Poster
Division of Organic Chemistry |