ORGN 307 |
| We have been exploring reactions that employ alpha-amino acids, and their derived peptides as catalysts for a variety of enantioselective and regioselective processes. Superficially, these catalysts appear to be much less complex than enzymes. Yet, correlations between structures and functions are rarely straightforward. This presentation will describe the discovery and use of peptides containing proteinogenic and non-natural amino acids for a variety of asymmetric bond formations. The connections between catalyst structure and function will be explored in a range of mechanistically distinct reactions. Prospects for generalizations and eventual design of catalysts from first principles will be evaluated. In addition, applications to the selective modification of complex molecules, including biologically active natural products, will be described. |
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Herbert C. Brown Award for Creative Research in Synthetic Methods: Symposium in Honor of Eric N. Jacobsen
1:30 PM-5:10 PM, Tuesday, April 8, 2008 Morial Convention Center -- La Nouvelle, Blrm. C, Oral
Division of Organic Chemistry |