Synthesis of acyl benzothiophenes via clean chemistry C-C bond forming reaction

ORGN 374

Sarbani Pal, sarbani277@yahoo.com1, Mohamma Ashrafuddin Khan2, P. Bindu2, and P. K. Dubey3. (1) Department of Chemistry, MNR Degree & PG college, PG Campus, Kukatpally, Hyderabad, 500072, India, (2) Department of Chemistry, MNR Post Graduate College, Kukatpally, Hyderabad, 500072, India, (3) Department of Chemistry, JNT University, Kukatpally, Hyderabad, 500072, India
A simple and single-step synthesis of 2- and 3-acyl substituted benzothiophenes has been developed via environmentally benign acylation of benzothiophene with in situ generated acyl trifluoroacetates. Both aliphatic and aromatic carboxylic acids participated in trifluoroacetic anhydride/ phosphoric acid mediated C-C bond forming reaction under a solvent-free condition affording acyl benzothiophenes in good overall yields.
 

Heterocycles and Aromatics, Molecular Recognition and Self Assembly
8:00 PM-10:00 PM, Tuesday, April 8, 2008 Morial Convention Center -- Hall A, Poster

Division of Organic Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008