ORGN 630 |
| (E)-1-Trimethylsilylmethyl-1-alkenylboronate esters easily prepared by reacting ( Z)-bromo-1-alkenylboronate esters with trimethylsilylmethyllithium, readily react with alkyl or aryllithium in ether at -78 oC for 2 h. The resulting products are then treated with iodine in methanol at -78 oC for 3 h to provide after workup the corresponding ( Z)-allylsilanes containing trimethylsilylmethyl moiety in good yields (66%-80%) These ( Z)-allylsilanes containing trimethylsilylmethyl moiety are purified by column chromatography over alumina and the structures of these compounds are confirmed by NMR spectral data. |
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Materials, Devices and Switches, Metal-Mediated Reactions, Asymmetric Reactions, Total Synthesis, Biologically-Related Molecules and Processes
7:00 PM-9:00 PM, Wednesday, April 9, 2008 Morial Convention Center -- La Louisiane, Blrm. C, Poster
Division of Organic Chemistry |