ORGNSunday, August 19, 2007
8:00 AM-11:40 AM BCEC -- 253 A/B/C, Oral
Combinatorial, Parallel, and Process Chemistry
Presiding:Xinhua Qian
8:00 AM9Triazolone formation in the synthesis of a PPAR alpha agonist: Development of a robust impurity control strategy
Jared W. Fennell, Steven E. Dunlap, Robert Metzler, Jeffrey T. Vicenzi, John A. Werner
8:20 AM10Application of rhodium(I)-catalyzed ene-allene carbocyclization strategy to prepare a library of alkyl- and alkylidene-oxepanecarboxamides
Shuli Mao, Kay M. Brummond
11Paper Withdrawn
8:40 AM12Combinatorial high throughput synthesis within continuous flow reactors
Paul Watts, Charlotte Wiles
9:00 AM13Development of a practical and large scale synthesis of a Statin Intermediate via Horner-Wittig olefination
Bin Zheng, Melissa Marchetti, Jason Zhu, Xinhua Qian, David Kacsur, Otute Akiti, Joydeep Kant, David Kronenthal
9:20 AM14Development of a practical synthesis of a potent, orally bioavailable calcitonin gene-related peptide (CGRP) receptor antagonist for the treatment of migraine
Dietrich Steinhuebel, Anthony Alorati, Michael Ashwood, Jenny Baxter, Kevin Belyk, Brian Bishop, Khateeta Emerson, Ian W. Davies, Andrew W. Gibson, Michael Palucki, Shane Krska, Yongkui Sun
9:40 AM15Efficient synthesis of 7-amino-3-hydroxyindan-1-one
Hwa-Ok Kim, Raj SB Rajur, Venugopal N. Rao, Pamela Nagafuji, Xavier Hearult, Norton P. Peet
10:00 AM16Parallel synthesis of 2-heteroaryl-substituted indole carboxylic acids
E. Jolicoeur, P. L. Beaulieu, D. Bykowski, J. R. Gillard
10:20 AM17Practical route to a melanin-concentrating hormone receptor 1 (MCHr1) antagonist
Denise L. Andersen, Pingli Liu, Thomas Storz, Xin Wang, Alan Allgeier, Jean Baum, Ying Chen, Rich Crockett, Liang Huang, Robert D. Larsen, Mike Martinelli
10:40 AM18Process development of a C-4 methylcarbonate analog of paclitaxcel
Rajendra Deshpande, Frank Gibson, Edward Gublo, Jason Hamm, Jun Li, Jing Liang, Karen Tenhuisen
11:00 AM19Process research and development toward a scaleable synthesis of a pyrazole-based CCK1 receptor antagonist: β-Enaminoketone as an armed intermediate for a regioselective pyrazole formation
Anusuya Choudhury, Tong Xiao, Jeffrey Grimm, Stephen Stefanick, Kirk L. Sorgi Sorgi, Neelakandha S. Mani, Jimmy Liang
11:20 AM20Phase transfer dynamic combinatorial chemistry
Ruth Pérez-Fernández, Jeremy K. M. Sanders

Symposium Grid -- Division of Organic Chemistry -- Session Listing

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007