CARB 39 |
| During this presentation, our laboratory's ongoing structural studies of protein-RNA complexes associated with recognition events along the siRNA and miRNA pathways will be discussed. Specifically, the contributions of structure-function to protein-RNA recognition events that monitor siRNA length, 5' phosphate, sugar-phosphate backbone, and two-nucleotide 3'-overhangs will be described. The architecture of the cleaving enzyme Argonaute (Ago), its externally bound siRNA complex, and Argonaute-based models involving guide-strand-mediated mRNA binding, cleavage, and release will also be discussed. |
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RNA Interference Based Therapeutics
8:30 AM-11:50 AM, Tuesday, August 21, 2007 BCEC -- 208, Oral
Division of Carbohydrate Chemistry |