ORGN 729 |
| A one-pot synthesis of the 2,3-dihydropyrrolo[3,2-c]quinoline core from substituted 2-haloanilines was achieved using 10 mol% Pd(PPh3)4 in dioxane at 170 °C for 1 hour in a microwave oven. The reaction can be scaled up to a gram scale. The proposed mechanism involves a Heck reaction followed by intra-molecular Schiff base formation and double bond migration.
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Combinatorial, Parallel and Process Chemistry, Heterocycles, Aromatics, New Reactions and Methodology
8:00 PM-10:00 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Organic Chemistry |
