Copper(I)-mediated amination of organostannanes with hydroxylamine derivatives

ORGN 732

Zhihui Zhang, zzhang6@emory.edu, Ying Yu, and Lanny S. Liebeskind. Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA 30322
Amination of organostannane reagents with hydroxylamine derivatives in the presence of stoichiometric copper is studied. A Cu (I) diphenylphosphinate (CuDPP) mediated amidation of organostannane with O-substituted hydroxamic acid gives amide as desired C-N bond formation product. Various amides can be synthesized from O-acetyl hydroxamic acids in good yields.

 

Combinatorial, Parallel and Process Chemistry, Heterocycles, Aromatics, New Reactions and Methodology
8:00 PM-10:00 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Organic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007